Article

Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of Irritable Bowel Syndrome

2022-05-12

Abstract excerpt

<title>Abstract</title> <p>Irritable bowel syndrome (IBS) is a prevalent functional disease. However, its molecular and pathological mechanisms are poorly understood. In this study, neonatal colorectal distension induced visceral hypersensitivity and anxiety comorbidity. The expression of hippocampal circKcnk9, a novel circRNA we termed, was increased significantly in IBS-like rats. Interesting, CA1 shcircKcnk9 t...

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Literature Corpus work: 2b6b0bd7-1de2-57b9-baaf-0a05ed344350
DOI: 10.21203/rs.3.rs-1555945/v1

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