Genomic instability: on the birth and death of cancer.

doi:10.1007/s12094-007-0042-3

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Article

Genomic instability: on the birth and death of cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Apr 2007

Murga M, Fernández-Capetillo O

Abstract excerpt

The presence of an abnormal chromosomal content is probably the most universally conserved hallmark of cancer cells. Predicted at the beginning of the 20th century as the origin of tumours, and extensively documented thereafter, genomic instability lies at the core of neoplastic development. Regardless of this classic model, the actual impact that deficient control of genomic integrity has on human health and...

Topics

Breast Neoplasms
Cellular Senescence
Clinical Trials as Topic
DNA Damage
DNA Repair
Female
Genetic Predisposition to Disease
Genetic Research
Genomic Instability
Humans
Lymphoma, B-Cell
Male
Mutation
Neoplasms
Oncogenes
Precancerous Conditions
Spectral Karyotyping

Source

Open in PubMed

Identifiers

PMID: 17462973
DOI: 10.1007/s12094-007-0042-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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