Article

Unexpected CRISPR off-target mutation pattern <i>in vivo</i> are not typically germline-like

2017-09-28

Abstract excerpt

<h4>To the Editor</h4> Schaefer et al. 1 (referred to as Study_1 ) recently presented the provocative conclusion that CRISPR-Cas9 nuclease can induce many unexpected off-target mutations across the genome that arise from the sites with poor homology to the gRNA. As Wilson et al. 2 pointed out, however, the selection of a co-housed mouse as the control is insufficient to attribute the observed mutation differen...

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Literature Corpus work: cfd3596b-7061-5c0d-8785-457f0ef7efc8
DOI: 10.1101/193565

Open publication

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