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Combined transcriptional, translational and cell surface targeted gene therapy of HER2-positive breast cancer stem cells in three-dimentional cell culture

2021-02-05

Abstract excerpt

<h4>Purpose: </h4> Breast Cancer Stem Cells (BCSCs) resist conventional treatments and cause tumor recurrence. Almost 25% of breast cancers overexpress human epidermal growth factor receptor-2 (HER2). Here we developed a novel multi-targeted nanosystem to specifically eradicate HER2-positive BCSCs. Methods Plasmids containing CXCR1 promoter, PE38 toxin and 5′UTR of the basic fibroblast growth factor-2 (bFGF 5'UTR...

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Literature Corpus work
cfc9fd7f-c3f5-51bd-80b0-87cea014d4bd
DOI
10.21203/rs.3.rs-184507/v1
Open publication

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Combined transcriptional, translational and cell surface targeted gene therapy of HER2-positive breast cancer stem cells in three-dimentional cell cultureDOI 10.21203/rs.3.rs-184507/v1
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