Article
The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy.
Biomaterials - 1 Apr 2012
Burke Andrew R, Singh Ravi N, Carroll David L, Wood James C S, D'Agostino Ralph B, Ajayan Pulickel M, Torti Frank M, Torti Suzy V
Abstract excerpt
Breast tumors contain a small population of tumor initiating stem-like cells, termed breast cancer stem cells (BCSCs). These cells, which are refractory to chemotherapy and radiotherapy, are thought to persist following treatment and drive tumor recurrence. We examined whether BCSCs are similarly resistant to hyperthermic therapy, and whether nanoparticles could be used to overcome this resistance. Using a model...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.