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Near-germline human monoclonal antibodies neutralize and protect against multiple arthritogenic alphaviruses

10 Sept 2021

Abstract excerpt

Arthritogenic alphaviruses are globally distributed, mosquito-transmitted viruses that cause rheumatological disease in humans and include Chikungunya virus (CHIKV), Mayaro virus (MAYV), and others. Although serological evidence suggests that some antibody-mediated heterologous immunity may be afforded by alphavirus infection, the extent to which broadly neutralizing antibodies that protect against multiple...

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PMID: 34507983
DOI: 10.1073/pnas.2100104118

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