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Article

Glucose PTS Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral Streptococci

2022-09-22

Abstract excerpt

Spontaneous mutants with defects in the primary glucose phosphotransferase (PTS) permease ( manLMNO ) of Streptococcus sanguinis SK36 showed enhanced fitness at low pH. Transcriptomics and metabolomics with a manL deletion mutant (SK36/ manL ) revealed redirection of pyruvate to production of acetate and formate, rather than lactate. The observations were consistent with measurements of decreased lactic acid a...

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Literature Corpus work
cfaeaf7e-e507-510a-8828-43342ae373ac
DOI
10.1101/2022.09.21.508965
Open publication

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