Article

Genetic Characterization of Glyoxalase Pathway in Oral Streptococci and its Contribution to Interbacterial Competition

2023-08-07

Abstract excerpt

Substantial quantities of Reactive Electrophile Species (RES), including methylglyoxal and glyoxal, are generated by microbes and humans. To understand the impact of RES on oral microbial homeostasis, genetic analyses were performed on the glyoxalase pathway in Streptococcus mutans (SMU) and Streptococcus sanguinis (SSA). Loss of glyoxalase I (LguL), which catalyzes the rate-limiting reaction in RES degradation,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16ea38b6-4d51-5f27-a99d-d6432b795dcf
DOI: 10.1101/2023.08.07.552317

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic Characterization of Glyoxalase Pathway in Oral Streptococci and its Contribution to Interbacterial CompetitionDOI 10.1101/2023.08.07.552317Read

FRUCTOSE ACTIVATES A STRESS RESPONSE SHARED BY METHYLGLYOXAL AND HYDROGEN PEROXIDE IN STREPTOCOCCUS MUTANSSemantic proximity Read

Glucose PTS Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral StreptococciSemantic proximity Read

Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?Semantic proximity Read

Aspects of oral streptococcal metabolic diversity: Imagining the landscape beneath the fogSemantic proximity Read

Bacterial Responses to Glyoxal and Methylglyoxal: Reactive Electrophilic SpeciesSemantic proximity Read

Glycerol Metabolism Contributes to Competition by Oral Streptococci through Production of Hydrogen PeroxideSemantic proximity Read

Spontaneous Mutants of Streptococcus sanguinis with Defects in the Glucose-PTS Show Enhanced Post-Exponential Phase FitnessSemantic proximity Read

Genetic variability of mutans streptococci revealed by wide whole-genome sequencing.Semantic proximity Read

Spontaneous Mutants of Streptococcus sanguinis with Defects in the Glucose-Phosphotransferase System Show Enhanced Post-Exponential-Phase FitnessSemantic proximity Read

Systematic Analysis of the Glucose-PTS in Streptococcus sanguinis Highlighted its Importance in Central Metabolism and Bacterial FitnessSemantic proximity Read

Involvement of gshAB in the interspecies competition within oral biofilm.Semantic proximity Read

Genomic and phenotypic characterization of Streptococcus mutans isolates suggests key gene clusters in regulating its interaction with Streptococcus gordoniiSemantic proximity Read