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Article

Phosphotransferase System Uptake and Metabolism of the β-Glucoside Salicin Impact Group A Streptococcal Bloodstream Survival and Soft Tissue Infection.

Infection and immunity - 18 Sept 2020

Braza Rezia Era, Silver Aliyah B, Sundar Ganesh S, Davis Sarah E, Razi Afrooz, Islam Emrul, Hart Meaghan, Zhu Jinyi, Le Breton Yoann, McIver Kevin S

Abstract excerpt

Streptococcus pyogenes (group A Streptococcus [GAS]), a major human-specific pathogen, relies on efficient nutrient acquisition for successful infection within its host. The phosphotransferase system (PTS) couples the import of carbohydrates with their phosphorylation prior to metabolism and has been linked to GAS pathogenesis. In a screen of an insertional mutant library of all 14 annotated PTS permease (EIIC)...

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Identifiers

PMID: 32719156
DOI: 10.1128/IAI.00346-20
PMCID: PMC7504967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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