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Systematic analysis of the glucose-PTS in Streptococcus sanguinis highlighted its importance in central metabolism and bacterial fitness

25 Nov 2024

Abstract excerpt

ABSTRACT Previous work reported that deletion of the Enzyme IIAB subunits (EIIAB Man and manL ) of the glucose phosphotransferase system (PTS) (glucose-PTS, manLMNO ) in Streptococcus sanguinis impacted carbon catabolite repression and bacterial fitness. Here, a single-nucleotide polymorphism in ManN, ManNA91E, produced the unusual phenotype of increased excretion of organic acids and H 2 O 2 yet elevated PTS...

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PMID: 39584828
DOI: 10.1128/aem.01935-24

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