Article
Predicting Evolution Using Regulatory Architecture.
Annual review of biophysics - 6 May 2020
Nghe Philippe, de Vos Marjon G J, Kingma Enzo, Kogenaru Manjunatha, Poelwijk Frank J, Laan Liedewij, Tans Sander J
Abstract excerpt
The limits of evolution have long fascinated biologists. However, the causes of evolutionary constraint have remained elusive due to a poor mechanistic understanding of studied phenotypes. Recently, a range of innovative approaches have leveraged mechanistic information on regulatory networks and cellular biology. These methods combine systems biology models with population and single-cell quantification and with...
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