Article
Analysis of in vitro evolution reveals the underlying distribution of catalytic activity among random sequences.
Nucleic acids research - 21 Aug 2017
Pressman Abe, Moretti Janina E, Campbell Gregory W, Müller Ulrich F, Chen Irene A
Abstract excerpt
The emergence of catalytic RNA is believed to have been a key event during the origin of life. Understanding how catalytic activity is distributed across random sequences is fundamental to estimating the probability that catalytic sequences would emerge. Here, we analyze the in vitro evolution of triphosphorylating ribozymes and translate their fitnesses into absolute estimates of catalytic activity for hundreds...
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