Article

Improving polygenic prediction from summary data by learning patterns of effect sharing across multiple phenotypes

2024-05-10

Abstract excerpt

Polygenic prediction of complex trait phenotypes has become important in human genetics, especially in the context of precision medicine. Recently, Morgante et al . introduced mr.mash , a flexible and computationally efficient method that models multiple phenotypes jointly and leverages sharing of effects across such phenotypes to improve prediction accuracy. However, a drawback of mr.mash is that it requires i...

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Literature Corpus work: cf8f5ab5-ac76-5961-929f-a2f81f23a487
DOI: 10.1101/2024.05.06.592745

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