Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Changing the protease specificity for activation of a flavivirus, tick-borne encephalitis virus.

Journal of virology - 1 Sept 2008

Fischl Wolfgang, Elshuber Sigrid, Schrauf Sabrina, Mandl Christian W

Abstract excerpt

The infectivity of flavivirus particles depends on a maturation process that is triggered by the proteolytic cleavage of the precursor of the M protein (prM). This activation cleavage is naturally performed by ubiquitous cellular proteases of the furin family, which typically recognize the multibasic sequence motif R-X-R/K-R. Previously, we demonstrated that a tick-borne encephalitis virus (TBEV) mutant with an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chymotrypsin
Share to Cricetinae
Share to Encephalitis Viruses, Tick-Borne

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Feasibility Studies

Share to Sensitivity and Specificity

Share to Sequence Analysis, Protein

Share to Trypsin

Share to Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18562534
DOI: 10.1128/JVI.00587-08
PMCID: PMC2519671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Changing the protease specificity for activation of a flavivirus, tick-borne encephalitis virus.PMID 18562534Read ↗

Resuscitating mutations in a furin cleavage-deficient mutant of the flavivirus tick-borne encephalitis virus.Semantic proximity Read ↗

Cleavage of protein prM is necessary for infection of BHK-21 cells by tick-borne encephalitis virus.Semantic proximity Read ↗

SARS-CoV-2 S Mutations: A Lesson from the Viral World to Understand How Human Furin Works.Semantic proximity Read ↗

Differential Modulation of prM Cleavage, Extracellular Particle Distribution, and Virus Infectivity by Conserved Residues at Nonfurin Consensus Positions of the Dengue Virus pr-M JunctionSemantic proximity Read ↗

Increased Cleavage of Japanese Encephalitis Virus prM Protein Promotes Viral Replication but Attenuates VirulenceSemantic proximity Read ↗

Genetically Engineered DENV Produces Antigenically Distinct Mature ParticlesSemantic proximity Read ↗

Reverse Genetics Demonstrates that Proteolytic Processing of the Ebola Virus Glycoprotein Is Not Essential for Replication in Cell CultureSemantic proximity Read ↗

Generation and preliminary characterization of vertebrate-specific replication-defective Zika virus.Semantic proximity Read ↗

Modification of the trypsin-dependent cleavage activation site of the human metapneumovirus fusion protein to be trypsin independent does not increase replication or spread in rodents or nonhuman primates.Semantic proximity Read ↗

Gemin5 proteolysis reveals a novel motif to identify L protease targetsSemantic proximity Read ↗

Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin.Semantic proximity Read ↗

Filoviruses Require Endosomal Cysteine Proteases for Entry but Exhibit Distinct Protease PreferencesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.