Article

Dissecting the oncogenic mechanisms of POT1 cancer mutations through deep scanning mutagenesis

2024-08-19

Abstract excerpt

Mutations in the shelterin protein POT1 are associated with diverse cancers, but their role in cancer progression remains unclear. To resolve this, we performed deep scanning mutagenesis in POT1 locally haploid human stem cells to assess the impact of POT1 variants on cellular viability and cancer-associated telomeric phenotypes. Though POT1 is essential, frame-shift mutants are rescued by chemical ATR inhibition,...

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Literature Corpus work: cf8d2896-74a4-5f39-ac8a-f7c9fc9fc620
DOI: 10.1101/2024.08.19.608636

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