Article

Enhancing mitochondrial activity in neurons protects against neurodegeneration in CNS inflammation

2020-06-20

Abstract excerpt

<h4>ABSTRACT</h4> Central nervous system (CNS) inflammation in multiple sclerosis (MS) drives neuro-axonal loss resulting in irreversible disability. While transcripts of mitochondrial genes are strongly suppressed in neurons during CNS inflammation, it is unknown whether this results in mitochondrial dysfunction and whether interventions that increase mitochondrial function can rescue neurodegeneration. Here we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cf6ffd0a-4f1d-52de-911e-e5a6e5ae80ae
DOI: 10.1101/2020.06.19.161091

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enhancing mitochondrial activity in neurons protects against neurodegeneration in CNS inflammationDOI 10.1101/2020.06.19.161091Read

Dysregulation of PGC-1α-Dependent Transcriptional Programs in Neurological and Developmental Disorders: Therapeutic Challenges and OpportunitiesSemantic proximity Read

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosisSemantic proximity Read

MS-driven metabolic alterations are recapitulated in iPSC-derived astrocytesSemantic proximity Read

Mitochondrial Dysfunction and Multiple SclerosisSemantic proximity Read

PGC-1α sparks the fire of neuroprotection against neurodegenerative disordersSemantic proximity Read

Early derangement of axonal mitochondria occurs in a mouse model of progressive but not relapsing-remitting multiple sclerosisSemantic proximity Read

Impaired Myelination in Multiple Sclerosis Organoids: p21 Links Oligodendrocyte Dysfunction to Disease SubtypeSemantic proximity Read

Effects of EHP-101 on inflammation and remyelination in murine models of Multiple SclerosisSemantic proximity Read

A mitochondrial component of neurodegeneration in multiple sclerosis.Semantic proximity Read

Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environmentSemantic proximity Read

Decreased mRNA Expression of PGC-1α and PGC-1α-Regulated Factors in the SOD1<sup>G93A</sup>ALS Mouse Model and in Human Sporadic ALSSemantic proximity Read

A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis.Semantic proximity Read