Article

A guide for establishing patient-derived organoids from bile samples obtained during endoscopic procedures and performing gene expression knockdown

2026-03-05

Abstract excerpt

Bile represents a clinically accessible biological fluid that can mitigates major limitations associated with tissue-based sampling for the generation of organoid models to study hepatobiliary disease, including biliary tract cancers where tissue availability is often limited. Importantly, bile can also enable the generation of non-malignant cholangiocyte organoids that are otherwise difficult to obtain. Here, we...

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Literature Corpus work: cf6d9100-14b6-52c2-a0b1-d59427566efb
DOI: 10.64898/2026.03.03.709312

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