Article
Cholangiocyte organoids from human bile retain a local phenotype and can repopulate bile ducts in vitro.
Clinical and translational medicine - 1 Dec 2021
Roos Floris J M, Wu Haoyu, Willemse Jorke, Lieshout Ruby, Albarinos Laura A Muñoz, Kan Yik-Yang, Poley Jan-Werner, Bruno Marco J, de Jonge Jeroen, Bártfai Richard, Marks Hendrik, IJzermans Jan N M, Verstegen Monique M A, van der Laan Luc J W
Abstract excerpt
The well-established 3D organoid culture method enabled efficient expansion of cholangiocyte-like cells from intrahepatic (IHBD) and extrahepatic bile duct (EHBD) tissue biopsies. The extensive expansion capacity of these organoids enables various applications, from cholangiocyte disease modelling to bile duct tissue engineering. Recent research demonstrated the feasibility of culturing cholangiocyte organoids...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.