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A 3D Bioprinted Spheroid Model of Nasopharyngeal Carcinoma Uncovers Constitutive IGF‑1R/PI3K/AKT Signaling as a Mediator of Intrinsic Cetuximab Resistance and a Therapeutic Vulnerability

2026-06-29

Abstract excerpt

<title>Abstract</title> <p>Nasopharyngeal carcinoma (NPC) is an epithelial malignancy endemic to Southern China and Southeast Asia and is closely associated with Epstein–Barr virus infection. In the recurrent/metastatic stage, NPC exhibits marked intrinsic resistance to cetuximab, yet the underlying mechanisms remain incompletely elucidated. Conventional two-dimensional (2D) culture fails to faithfully recapitula...

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Literature Corpus work: cf45daa5-9d29-51fa-84c5-4f914395fdeb
DOI: 10.21203/rs.3.rs-10014915/v1

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A 3D Bioprinted Spheroid Model of Nasopharyngeal Carcinoma Uncovers Constitutive IGF‑1R/PI3K/AKT Signaling as a Mediator of Intrinsic Cetuximab Resistance and a Therapeutic VulnerabilityDOI 10.21203/rs.3.rs-10014915/v1Read

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