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CAV2 Confers Cetuximab Resistance in HNSCC by Ubiquitin-Mediated Disruption of the PACT-PKR Tumor Suppressor Axis

2026-03-04

Abstract excerpt

<h4>Background: </h4> /Objectives: Head and neck squamous cell carcinoma (HNSCC) frequently exhibits resistance to targeted therapies, including cetuximab. Identifying key drivers of tumor progression and elucidating the mechanisms underlying therapeutic resistance are essential for improving clinical outcomes. This study aimed to investigate the role of Caveolin-2 (CAV2) in HNSCC proliferation and cetuximab resis...

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Literature Corpus work
135d4d58-cd73-59bf-b507-4a0ae44c27e5
DOI
10.20944/preprints202603.0337.v1
Open publication

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