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Article

Development of cetuximab-resistant human nasopharyngeal carcinoma cell lines and mechanisms of drug resistance.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Oct 2010

Zuo Qiang, Shi Min, Li Libo, Chen Jinzhang, Luo Rongcheng

Abstract excerpt

This work aimed to explore the induction of cetuximab-resistant human nasopharyngeal carcinoma (hNPC) 5-8F/Erbitux cells and the mechanisms of drug resistance. The 5-8F cells with high EGFR expression and cetuximab sensitivity were screened and then induced by stepwise exposure to increasing doses of cetuximab. Western blot was conducted to detect protein levels. Our results are as follows: we successfully...

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Share to Antibodies, Monoclonal
Share to Antibodies, Monoclonal, Humanized

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cetuximab

Share to Drug Resistance, Neoplasm

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Share to Nasopharyngeal Neoplasms

Share to PTEN Phosphohydrolase

Source

Identifiers

PMID: 20630698
DOI: 10.1016/j.biopha.2010.03.003

Genes

PTEN
EGFR

Provenance

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