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Article

JNK-mediated activation of ATF2 contributes to dopaminergic neurodegeneration in the MPTP mouse model of Parkinson's disease.

Experimental neurology - 1 Mar 2016

Huang Qiaoying, Du Xiaoxiao, He Xin, Yu Qing, Hu Kunhua, Breitwieser Wolfgang, Shen Qingyu, Ma Shanshan, Li Mingtao

Abstract excerpt

The c-Jun N-terminal kinase (JNK)/c-Jun pathway is a known critical regulator of dopaminergic neuronal death in Parkinson's disease (PD) and is considered a potential target for neuroprotective therapy. However, whether JNK is activated within dopaminergic neurons remains controversial, and whether JNK acts through downstream effectors other than c-Jun to promote dopaminergic neuronal death remains unclear. In...

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Source

Identifiers

PMID: 26515688
DOI: 10.1016/j.expneurol.2015.10.010

Genes

ATF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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