Article

Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition

2024-06-25

Abstract excerpt

Varicella zoster virus (VZV) is a human-specific herpesvirus that establishes latency in peripheral neurons. The only transcripts detected in infected human trigeminal ganglia (TG) obtained shortly after death correspond to the VZV latency-associated transcript (VLT) and associated VLT-ORF63 splice variants. In vitro studies showed that VLT-ORF63 is translated into a protein (pVLT-ORF63) that induces VZV transcri...

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Literature Corpus work: cef4b484-f060-5513-91c8-05ab3b533df9
DOI: 10.1101/2024.06.25.600588

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