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Article

Restarting Lytic Gene Transcription at the Onset of Herpes Simplex Virus Reactivation

3 Nov 2016

Abstract excerpt

Herpes simplex virus (HSV) establishes a latent reservoir in neurons of human peripheral nerves. In this quiescent state, the viral genome persists as a circular, histone-associated episome, and transcription of viral lytic cycle genes is largely suppressed through epigenetic processes. Periodically, latent virus undergoes reactivation whereby lytic genes are activated and viral replication occurs. In this Gem,...

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PMID: 27807236
DOI: 10.1128/jvi.01419-16

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