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Expression of varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency

2020-09-11

Abstract excerpt

<h4>Summary</h4> Varicella-zoster virus (VZV) establishes lifelong neuronal latency in most humans world-wide, reactivating in one-third to cause herpes zoster and occasionally chronic pain. How VZV establishes, maintains and reactivates from latency is largely unknown. Latent VZV gene expression is restricted to VZV latency-associated transcript (VLT) and open reading frame 63 (ORF63) in naturally VZV-infected h...

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Identifiers and source

Literature Corpus work
23356c01-04af-5a84-b86a-43fe3df2b9ab
DOI
10.1101/2020.09.11.294280
Open publication

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Expression of varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latencyDOI 10.1101/2020.09.11.294280
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