Article
Identification of novel splice variants of ARNT and ARNT2 in the rat.
Biochemical and biophysical research communications - 18 Apr 2003
Korkalainen Merja, Tuomisto Jouko, Pohjanvirta Raimo
Abstract excerpt
Most of the biochemical and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are mediated by the bHLH/PAS protein AH receptor (AHR). For regulation of gene activities, AHR dimerizes with another member of the bHLH/PAS protein family, AHR nuclear translocator (ARNT). A substrain of Wistar rats, Han/Wistar (Kuopio) (H/W), is about 1000-fold more resistant to the acute lethality of TCDD than other...
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