Article

Huntington’s disease-associated ankyrin repeat palmitoyl transferases are rate-limiting factors in lysosome formation and fusion

2025-02-08

Abstract excerpt

Protein palmitoylation in the Golgi apparatus is critical for the appropriate sorting of various proteins belonging to secretory and lysosomal systems, and defective palmitoylation can lead to the onset of severe pathologies. HIP14 and HIP14L ankyrin repeat-containing palmitoyl transferases were linked to the pathogenesis of Huntington’s disease, however, how perturbation of these Golgi resident enzymes contribute...

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Literature Corpus work: cec1472d-c5de-5eea-b3a7-d97bf799b1f0
DOI: 10.1101/2025.02.06.636816

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