Article
Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics.
Seminars in arthritis and rheumatism - 1 Oct 2009
Herrero-Beaumont Gabriel, Roman-Blas Jorge A, Castañeda Santos, Jimenez Sergio A
Abstract excerpt
BACKGROUND: Osteoarthritis (OA) has been historically divided into primary and secondary. Primary OA has been defined as an idiopathic condition developing in previously undamaged joints in the absence of an obvious causative mechanism. During the last few years a large amount of evidence has provided new insights into the biochemistry and molecular biology of cartilage, subchondral bone, and other articular...
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