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Article

Genomic Aberrations in Crizotinib Resistant Lung Adenocarcinoma Samples Identified by Transcriptome Sequencing.

PloS one - 1 Jan 2016

Saber Ali, van der Wekken Anthonie J, Kok Klaas, Terpstra M Martijn, Bosman Lisette J, Mastik Mirjam F, Timens Wim, Schuuring Ed, Hiltermann T Jeroen N, Groen Harry J M, van den Berg Anke

Abstract excerpt

ALK-break positive non-small cell lung cancer (NSCLC) patients initially respond to crizotinib, but resistance occurs inevitably. In this study we aimed to identify fusion genes in crizotinib resistant tumor samples. Re-biopsies of three patients were subjected to paired-end RNA sequencing to identify fusion genes using deFuse and EricScript. The IGV browser was used to determine presence of known...

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Identifiers

PMID: 27045755
DOI: 10.1371/journal.pone.0153065
PMCID: PMC4821611

Genes

ALK
EML4
CLIP4
VSNL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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