Article

Cilia-independent requirements for Ccdc103 promoting proliferation and migration of myeloid cells

2020-11-25

Abstract excerpt

The pathology of primary ciliary dyskinesia (PCD) is predominantly attributed to impairment of motile cilia. However, PCD patients also have perplexing functional defects in myeloid cells, which lack motile cilia. Here, we show Coiled-coiled domain containing protein 103 (CCDC103), mutations in which underlie PCD, is required for the proliferation and directed migration of myeloid cells. CCDC103 co-localizes with...

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Literature Corpus work: ce74afd7-fa07-56f5-80ff-d8d312206794
DOI: 10.1101/2020.11.24.397026

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