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Article

Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival.

American journal of respiratory cell and molecular biology - 1 Jun 2013

Teves Maria Eugenia, Zhang Zhibing, Costanzo Richard M, Henderson Scott C, Corwin Frank D, Zweit Jamal, Sundaresan Gobalakrishnan, Subler Mark, Salloum Fadi N, Rubin Bruce K, Strauss Jerome F

Abstract excerpt

Primary ciliary dyskinesia (PCD), resulting from defects in cilia assembly or motility, is caused by mutations in a number of genes encoding axonemal proteins. PCD phenotypes are variable, and include recurrent respiratory tract infections, bronchiectasis, hydrocephaly, situs inversus, and male infertility. We generated knockout mice for the sperm-associated antigen-17 (Spag17) gene, which encodes a central pair...

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Source

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Identifiers

PMID: 23418344
DOI: 10.1165/rcmb.2012-0362OC
PMCID: PMC3727877

Genes

SPAG17
SPAG16
SPAG6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival.PMID 23418344Read ↗

A novel hypomorphic allele of Spag17 causes primary ciliary dyskinesia phenotypes in mice.Semantic proximity Read ↗

A novel hypomorphic allele of <i>Spag17</i> causes primary ciliary dyskinesia phenotypes in miceSemantic proximity Read ↗

SPAG17 Is Required for Male Germ Cell Differentiation and FertilitySemantic proximity Read ↗

Novel homozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella related to axonemal microtubule doublets.Semantic proximity Read ↗

Sperm-Associated Antigen 6 (SPAG6) Deficiency and Defects in Ciliogenesis and Cilia Function: Polarity, Density, and BeatSemantic proximity Read ↗

Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1.Semantic proximity Read ↗

Deficiency of SPAG16L Causes Male Infertility Associated with Impaired Sperm Motility1Semantic proximity Read ↗

Sperm Protein 17 Is Expressed in Human Somatic Ciliated EpitheliaSemantic proximity Read ↗

The role of SPAG1 in the assembly of axonemal dyneins in human airway epithelia.Semantic proximity Read ↗

Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms.Semantic proximity Read ↗

Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6.Semantic proximity Read ↗

Sperm defects in primary ciliary dyskinesia and related causes of male infertility.Semantic proximity Read ↗

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