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Article

Ccdc103 promotes myeloid cell proliferation and migration independent of motile cilia.

Disease models & mechanisms - 1 May 2021

Falkenberg Lauren G, Beckman Sarah A, Ravisankar Padmapriyadarshini, Dohn Tracy E, Waxman Joshua S

Abstract excerpt

The pathology of primary ciliary dyskinesia (PCD) is predominantly attributed to impairment of motile cilia. However, PCD patients also have perplexing functional defects in myeloid cells, which lack motile cilia. Here, we show that coiled-coil domain-containing protein 103 (CCDC103), one of the genes that, when mutated, is known to cause PCD, is required for the proliferation and directed migration of myeloid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34028558
DOI: 10.1242/dmm.048439
PMCID: PMC8214733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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