Article
Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1.
Molecular and cellular biology - 1 Feb 2008
Lee Lance, Campagna Dean R, Pinkus Jack L, Mulhern Howard, Wyatt Todd A, Sisson Joseph H, Pavlik Jacqueline A, Pinkus Geraldine S, Fleming Mark D
Abstract excerpt
Primary ciliary dyskinesia (PCD) results from ciliary dysfunction and is commonly characterized by sinusitis, male infertility, hydrocephalus, and situs inversus. Mice homozygous for the nm1054 mutation develop phenotypes associated with PCD. On certain genetic backgrounds, homozygous mutants die perinatally from severe hydrocephalus, while mice on other backgrounds have an accumulation of mucus in the sinus...
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