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Meta-analysis of CYP2C19 and CYP2D6 metabolic activity on antidepressant response from 13 clinical studies using genotype imputation

2023-06-28

Abstract excerpt

Cytochrome P450 enzymes including CYP2C19 and CYP2D6 are important for antidepressant metabolism and polymorphisms of these genes have been determined to predict metabolite levels. Nonetheless, more evidence is needed to understand the impact of genetic variations on antidepressant response. In this study, individual clinical and genetic data from 13 studies of European and East Asian ancestry populations were col...

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Literature Corpus work
ce70f226-c91f-5e4a-9aa6-04161fb62764
DOI
10.1101/2023.06.26.23291890
Open publication

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Meta-analysis of CYP2C19 and CYP2D6 metabolic activity on antidepressant response from 13 clinical studies using genotype imputationDOI 10.1101/2023.06.26.23291890
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