Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis.

doi:10.1038/s41398-024-02981-1

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Article

Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis.

Translational psychiatry - 19 Jul 2024

Li Danyang, Pain Oliver, Fabbri Chiara, Wong Win Lee Edwin, Lo Chris Wai Hang, Ripke Stephan, Cattaneo Annamaria, Souery Daniel, Dernovsek Mojca Z, Henigsberg Neven, Hauser Joanna, Lewis Glyn, Mors Ole, Perroud Nader, Rietschel Marcella, Uher Rudolf, Maier Wolfgang, Baune Bernhard T, Biernacka Joanna M, Bondolfi Guido, Domschke Katharina, Kato Masaki, Liu Yu-Li, Serretti Alessandro, Tsai Shih-Jen, Weinshilboum Richard, McIntosh Andrew M, Lewis Cathryn M

Abstract excerpt

Cytochrome P450 enzymes including CYP2C19 and CYP2D6 are important for antidepressant metabolism and polymorphisms of these genes have been determined to predict metabolite levels. Nonetheless, more evidence is needed to understand the impact of genetic variations on antidepressant response. In this study, individual clinical and genetic data from 13 studies of European and East Asian ancestry populations were...

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Identifiers

PMID: 39025838
DOI: 10.1038/s41398-024-02981-1
PMCID: PMC11258238

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Source receipt: pubmed, retrieved 7 Sept 2026.

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