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Integrating Genetic Variants and Expression Profiles of Pharmacogenes to Investigate Resistance to Antidepressant Treatment.

Medicina (Kaunas, Lithuania) - 15 May 2026

Pisanu Claudia, Squassina Alessio, Perera-Bel Júlia, Silva Rosana Carvalho, Buson Lisa, Sires Anna Martinez, Bortolomasi Marco, Menesello Valentina, Perusi Giulia, Carpiniello Bernardo, Ferensztajn-Rochowiak Ewa, Rybakowski Filip, Sanz Ferran, Manchia Mirko, Potier Marie Claude, Dierssen Mara, Prompt Study Group, Baune Bernhard T, Gennarelli Massimo, Minelli Alessandra

Abstract excerpt

Background and Objectives: Treatment-resistant depression (TRD) is a major clinical challenge in the management of major depressive disorder (MDD). While pharmacogenetics has been suggested to be clinically useful in guiding antidepressant treatment, few studies have explored if and how pharmacogenes can be involved in TRD pathophysiology and its clinical outcomes. Material amd Methods: We explored the role of...

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Source

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Identifiers

PMID: 42195218
DOI: 10.3390/medicina62050965
PMCID: PMC13209118

Genes

TRD
CYP2C19
CYP2B6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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