Article
Effect of CYP2C19 polymorphisms on antidepressant prescription patterns and treatment emergent mania in bipolar disorder.
The pharmacogenomics journal - 1 Jan 2023
Joas Erik, Jonsson Lina, Viktorin Alexander, Smedler Erik, Pålsson Erik, Goodwin Guy M, Landén Mikael
Abstract excerpt
Antidepressant medication is used extensively to treat bipolar depression despite uncertain efficacy. The cytochrome P450 (CYP) 2C19 enzyme metabolize several antidepressants, and polymorphisms in the corresponding gene CYP2C19 influence plasma concentration and hence treatment outcomes in major depressive disorder. Here, we investigate if CYP2C19 polymorphisms are associated with antidepressant treatment...
Topics
- Humans
- Amitriptyline
- Antidepressive Agents
- Bipolar Disorder
- Clomipramine
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Depressive Disorder, Major
- Mania
- Polymorphism, Single Nucleotide
- Sertraline