Article

Non-homologous end joining pathway of the human pathogen Cryptococcus neoformans influences homologous integration efficiency but not virulence

2010-07-01

Abstract excerpt

The efficiency of gene targeting by integration through homologous recombination (homologous integration, HI) in the human pathogen Cryptococcus neoformans remains unsatisfactory. In order to achieve a much more efficient gene targeting system in C. neoformans, a new double knockout strain in genes involved in the non-homologous end joining (NHEJ) pathway was constructed. HI frequency was elevated by as much as ap...

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Literature Corpus work: ce68f2f7-ffcd-5655-b46e-64622d7f7208
DOI: 10.1007/s10267-010-0038-7

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