Article

Ketone and glycolytic metabolism are key modulators of inflammation during neonatal sepsis

2025-08-19

Abstract excerpt

Neonatal sepsis is a life-threatening condition in preterm infants, primarily due to a dysregulated immunometabolic response to infection. Sepsis and infection mortality are associated with excessive glycolysis-induced inflammation, impaired mitochondrial oxidative phosphorylation (OXPHOS) and loss of disease tolerance. Reduced glucose intake can reverse these dysregulations, but it is unclear how the mechanistic...

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Identifiers and source

Literature Corpus work: ce58a749-a66a-561c-bd6c-2690e7b295fc
DOI: 10.1101/2025.08.15.670527

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