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Regulation of host metabolism and defense strategies to survive neonatal infection

29 Aug 2024

Abstract excerpt

Two distinct defense strategies, disease resistance (DR) and disease tolerance (DT), enable a host to survive infectious diseases. Newborns, constrained by limited energy reserves, predominantly rely on DT to cope with infection. However, this approach may fail when pathogen levels surpass a critical threshold, prompting a shift to DR that can lead to dysregulated immune responses and sepsis. The mechanisms...

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PMID: 39213794
DOI: 10.1016/j.bbadis.2024.167482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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