Article

Regulation of host metabolism and defense strategies to survive neonatal infection

2024-02-27

Abstract excerpt

Two distinct defense strategies, resistance and tolerance, enable a host to survive infectious diseases. Newborns, constrained by limited energy reserves, predominantly rely on tolerance to cope with infection. However, this approach may fail as pathogen levels surpass a critical threshold, prompting a shift to resistance that can lead to dysregulated immune responses and sepsis. The mechanisms governing the inter...

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Literature Corpus work: 806b632e-9380-5539-9f1c-10225efc86e2
DOI: 10.1101/2024.02.23.581534

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