Molecular dynamics simulations reveal a mechanism of calcium homeostasis driving homotrimerisation and heterotrimerization of type I collagen

Abstract excerpt

Type I collagen is the main structural protein of vertebrates and forms molecular trimers from the COL1A1 and COL1A2 gene products; pro-alpha-1(I) and pro-alpha-2(I)), during biosynthesis. The amino acid sequence of the C-propeptide of collagen, which is removed before collagen fibril formation, initially drives heterotrimerisation and calcium ions are required for trimers to form. The homotrimeric form is associa...

Topics

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• Collagen Type I
• Collagen Type I, alpha 1 Chain
• Crystallography, X-Ray
• Genetic Vectors
• Protein Conformation, alpha-Helical
• Protein Conformation, beta-Strand
• Protein Interaction Domains and Motifs
• Protein Multimerization

Identifiers and source

Literature Corpus work

ce4f3c69-06a8-5a02-b264-d19ecde80339

DOI

10.1101/2025.04.03.646381