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Article

Segregation of type I collagen homo- and heterotrimers in fibrils.

Journal of molecular biology - 31 Oct 2008

Han Sejin, McBride Daniel J, Losert Wolfgang, Leikin Sergey

Abstract excerpt

Normal type I collagen is a heterotrimer of two alpha1(I) and one alpha2(I) chains, but various genetic and environmental factors result in synthesis of homotrimers that consist of three alpha1(I) chains. The homotrimers completely replace the heterotrimers only in rare recessive disorders. In the general population, they may compose just a small fraction of type I collagen. Nevertheless, they may play a...

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Identifiers

PMID: 18721810
DOI: 10.1016/j.jmb.2008.08.008
PMCID: PMC2839200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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