Article

TGF-β mediated synthesis of degradation-resistant collagen (I) homotrimer in musculoskeletal cells

2019-01-01

Abstract excerpt

Type I collagen is the most abundant structural protein in vertebrates. It is the main component of the extracellular matrix in the majority of musculoskeletal tissues, including bone, muscle, tendon and ligament. Type I collagen usually occurs as a heterotrimer, of two alpha-1 chains and one alpha-2 chain (a1(I))2(a2(I)) encoded by the COL1A1 and COL1A2 genes. However, type I collagen can form homotrimers (a1(I))...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6b8215d-ca7a-52f5-b019-8fe681de7be5
DOI: 10.17638/03046507

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TGF-β mediated synthesis of degradation-resistant collagen (I) homotrimer in musculoskeletal cellsDOI 10.17638/03046507Read

Reviewing the Regulators of COL1A1Semantic proximity Read

Enigmatic insight into collagenSemantic proximity Read

The collagen superfamily--diverse structures and assemblies.Semantic proximity Read

The collagen family.Semantic proximity Read

The biology of the extracellular matrixSemantic proximity Read

Collagen fibril assembly: New approaches to unanswered questionsSemantic proximity Read

Matrix TurnoverSemantic proximity Read

How is Type I procollagen synthesis regulated at the gene level during tissue fibrosisSemantic proximity Read

Collagens: molecular biology, diseases, and potentials for therapy.Semantic proximity Read

Transforming Growth Factor Beta Family: Insight into the Role of Growth Factors in Regulation of Fracture Healing Biology and Potential Clinical ApplicationsSemantic proximity Read

Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis.Semantic proximity Read

Structural basis of homo- and heterotrimerization of collagen I.Semantic proximity Read