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Article

Molecular mechanism of calcium induced trimerization of C1q-like domain of otolin-1 from human and zebrafish.

Scientific reports - 17 Jun 2021

Hołubowicz Rafał, Ożyhar Andrzej, Dobryszycki Piotr

Abstract excerpt

The C1q superfamily includes proteins involved in innate immunity, insulin sensitivity, biomineralization and more. Among these proteins is otolin-1, which is a collagen-like protein that forms a scaffold for the biomineralization of inner ear stones in vertebrates. The globular C1q-like domain (gC1q), which is the most conserved part of otolin-1, binds Ca2+ and stabilizes its collagen-like triple helix. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34140580
DOI: 10.1038/s41598-021-92129-8
PMCID: PMC8211825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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