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Article

Antibody Properties Associate with Clinical Phenotype in LGI1 Encephalitis.

Cells - 11 Jan 2023

Ludewig Susann, Salzburger Leonie, Goihl Alexander, Rohne Jana, Leypoldt Frank, Bittner Daniel, Düzel Emrah, Schraven Burkhart, Reinhold Dirk, Korte Martin, Körtvélyessy Péter

Abstract excerpt

Autoimmune encephalitis (AE) associated with autoantibodies against leucine-rich glioma-inactivated protein-1 (LGI1) can present with faciobrachial dystonic seizures (FBDS) and/or limbic encephalitis (LE). The reasons for this heterogeneity in phenotypes are unclear. We performed autoantibody (abs) characterization per patient, two patients suffering from LE and two from FBDS, using isolated antibodies specified...

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Identifiers

PMID: 36672216
DOI: 10.3390/cells12020282
PMCID: PMC9856817

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