Article

Sustained pigmentation causes DNA damage and invokes translesion polymerase Pol κ for repair in melanocytes

2022-05-25

Abstract excerpt

The pigment melanin protects skin cells from ultraviolet (UV) radiation induced DNA damage. However, intermediates of eumelanin are highly reactive quinones that are potentially genotoxic. In this study, we systematically investigate the effect of sustained elevation of melanogenesis and map the consequent cellular repair response of melanocytes. Pigmentation increases DNA damage, causes cell cycle arrest, and inv...

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Identifiers and source

Literature Corpus work: 18d136de-b086-5aaa-a4f0-1740d4cd70b3
DOI: 10.1101/2022.05.20.492761

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