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Article

Genotype-Encoded UV Sensitivity in iPSC-Derived Human Melanocytes Reveals MX2 as a Physiological Amplifier of p53/p38-Mediated DNA Damage Signaling.

International journal of molecular sciences - 12 Mar 2026

Ramirez-Salazar Eric, Slipicevic Ana, Juraleviciute Marina, Li Ling, Harland Mark, O'Shea Sally, Field Sinead, Newton-Bishop Julia, Herlyn Meenhard

Abstract excerpt

Ultraviolet (UV) radiation induces DNA damage and oxidative stress in melanocytes, shaping pigmentation phenotypes and elevating photocarcinogenesis risk. Human models that capture donor-linked genetic determinants of UV sensitivity remain limited. Here, we establish a genotype-informed UV response model using induced pluripotent stem cell (iPSC)-derived melanocytes from donors carrying defined MC1R variants....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to p38 Mitogen-Activated Protein Kinases

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Source

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Identifiers

PMID: 41898480
DOI: 10.3390/ijms27062617
PMCID: PMC13027049

Genes

MX2
CPD
MC1R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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