Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence.

doi:10.1371/journal.pone.0003926

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Article

Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence.

PloS one - 1 Jan 2008

Zhou Jianfeng, Li Wenhong, Kamei Hiroyasu, Duan Cunming

Abstract excerpt

BACKGROUND: Insulin-like growth factor binding protein-2 (IGFBP-2) is a secreted protein that binds and regulates IGF actions in controlling growth, development, reproduction, and aging. Elevated expression of IGFBP-2 is often associated with progression of many types of cancers. METHODOLOGY/PRINCIPAL FINDINGS: We report the identification and characterization of two IGFBP-2 genes in zebrafish and four other...

Topics

Amino Acid Sequence
Animals
Body Patterning
Cell Lineage
Embryo, Nonmammalian
Embryonic Development
Evolution, Molecular
Fishes
Gene Duplication
Gene Expression Regulation, Developmental
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heparin

Insulin-Like Growth Factor Binding Protein 2

Integrins

Molecular Sequence Data

Phylogeny

Protein Binding

Somatomedins

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Identifiers

PMID: 19081843
DOI: 10.1371/journal.pone.0003926
PMCID: PMC2593780

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