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Article

Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence.

PloS one - 1 Jan 2008

Zhou Jianfeng, Li Wenhong, Kamei Hiroyasu, Duan Cunming

Abstract excerpt

BACKGROUND: Insulin-like growth factor binding protein-2 (IGFBP-2) is a secreted protein that binds and regulates IGF actions in controlling growth, development, reproduction, and aging. Elevated expression of IGFBP-2 is often associated with progression of many types of cancers. METHODOLOGY/PRINCIPAL FINDINGS: We report the identification and characterization of two IGFBP-2 genes in zebrafish and four other...

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PMID: 19081843
DOI: 10.1371/journal.pone.0003926
PMCID: PMC2593780

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