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Sexual dimorphic effects of igf1 deficiency on metabolism in zebrafish

29 Jul 2022

Abstract excerpt

Insulin-like growth factor 1 (IGF1) is an essential effector of the growth hormone (GH)/IGF1 axis for somatic growth regulation in mammals. However, its functions have not been thoroughly investigated in zebrafish in vivo. In this study, the igf1-deficient zebrafish model was developed using the CRISPR/Cas9 technique. In this study all the results were performed on both male and female animals. The growth of both...

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PMID: 35966057
DOI: 10.3389/fendo.2022.879962

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